The Latest Clinical Articles in Endocrinology & Diabetes

1Efficacy and safety of linagliptin co-administered with low-dose metformin once daily versus high-dose metformin twice daily in treatment-naïve patients with type 2 diabetes: a double-blind randomized trialAdvances in Therapy, March 31, 2015  Clinical Article
2The association between glucose-lowering drug use and mortality among breast cancer patients with type 2 diabetesBreast Cancer Research and Treatment, March 31, 2015  Clinical Article
3The role of preanalytical glycolysis in the diagnosis of gestational diabetes mellitus in obese womenAmerican Journal of Obstetrics and Gynecology, March 31, 2015  Clinical Article
4Factors associated with untreated diabetes: analysis of data from 20,496 participants in the Japanese National Health and Nutrition SurveyPLOS ONE, March 31, 2015  Clinical Article
5The association between diabetes and breast cancer stage at diagnosis: a population-based studyBreast Cancer Research and Treatment, March 31, 2015  Clinical Article
6Pancreatic cancer-associated diabetes is an “Exosomopathy”Clinical Cancer Research, March 31, 2015  Review Article
7The influence of familial predisposition to cardiovascular complications upon childhood obesity treatmentPLOS ONE, March 31, 2015  Clinical Article
8Pilot study of exercise therapy on painful diabetic peripheral neuropathyPain Medicine, March 31, 2015  Clinical Article
9Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational statusBMC Cancer, March 31, 2015  Full Text  Clinical Article
10A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumorsBMC Cancer, March 31, 2015  Full Text  Clinical Article
1New study links urinary troubles at menopause with sleep, body fat, reaction timeThe North American Menopause Society News, March 31, 2015
2MAIT cell alterations involved in obesity and T2 diabetesCentre National de la Recherche Scientifique News, March 31, 2015
3IMRIC scientists find a surprising link between weaning and glucose metabolism, with implications for diabetes and cell regenerationThe Hebrew University of Jerusalem News, March 31, 2015
4Can our bones protect us against diabetes and obesity?Institut de recherches cliniques de Montréal News, March 31, 2015
5New study: Many diabetes patients with multiple comorbidities don’t get the best possible careTufts Medical Center News, March 31, 2015
6FDA approves new treatment for diabetic retinopathy in patients with diabetic macular edemaFDA Press Announcements, March 31, 2015
7Researchers reverse type 2 diabetes and fatty liver diseaseUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
8Study suggests precision medicine for adrenal cancerUniversity of Michigan Health System, March 30, 2015
9Danish Researchers' breakthrough identification of important proteinUniversity of Copenhagen Faculty of Health and Medical Sciences News, March 30, 2015
10Weight discrimination has major impact on quality of lifeUniversity College London New, March 30, 2015

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Parenteral vitamin D improves insulin sensitivity

As reported in Swiss Medical Weekly, supplemental vitamin D3 (300,000 IU im) in patients (n=55) with T2DM of > 10 y duration resulted in a 12.8% decrease in HOMA-IR at 6 months compared to an increase of 10% in patients who received placebo.

Vildegliptin superior to glimepiride when added to metformin

As reported in Metabolism, addition of vildegliptin (50 mg bid) to metformin in T2DM patients inadequately controlled on metformin alone was superior to the addition of glimepiride (2 mg tid) to metformin. Patients on the vildegliptin + metformin regimen lost more weight, had an improved lipid profile, had increased insulin sensitivity, and decreased post-prandial lipemia and insulinemia compared to patients on the glimepiride + metformin regimen.

Aspirin has a dose-independent effect in T2DM

As reported in The International Journal of Clinical Practice, the dose of aspirin (75 mg/d, 300 mg/d, or 3.6 g/d) had an independent effect on markers of vascular inflammation, oxidative stress, insulin resistance, and endothelial function in patients with T2DM (n=17; mean age = 57.4 y).

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Clinical Pearls

Clinical Pearl from Smartest DocBariatric surgery is approved by the FDA for use in patients with a BMI between 30 and 35 who have type 2 diabetes.

Clinical Pearl from Smartest DocDiabetes remission rate at 15 years post bariatric surgery is 31%.

Clinical Pearl from Smartest DocAggressive BP control may increase the risk of CHD in patients with diabetes.

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