MDLinx Endocrinology Overview: Our medical editors have ranked and organized papers in the top peer-reviewed clinical journals by topic including diabetes types 1 and 2, thyroid and glandular diseases, obesity and dyslipidemia. In a matter of minutes, you and all the members of your patient care team can stay current on the literature as it is published.
Also on this page: MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD, and clinical pearls from The Smartest Diabetes Expert as well as endocrinology topics in The Smartest Internist, The Smartest Family Physician, and The Smartest Pediatrician daily quiz challenges.
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1 Effect of lifestyle modification on serum chemerin concentration and its association with insulin sensitivity in overweight and obese adults with type 2 diabetes Clinical Endocrinology, May 22, 2013 Review Article
2 Circulating estrone levels are associated prospectively with diabetes risk in men of the framingham heart study Diabetes Care, May 22, 2013 Clinical Article
3 Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (grade) Diabetes Care, May 22, 2013 Review Article
4 Genetic variants and the risk of gestational diabetes mellitus: a systematic review Human Reproduction Update, May 22, 2013 Review Article
5 Aggressive blood pressure control increases coronary heart disease risk among diabetic patients Diabetes Care, May 22, 2013 Clinical Article
6 A specific and sensitive assay for blood levels of glycated CD59: a novel biomarker for diabetes American Journal of Hematology, May 22, 2013 Clinical Article
7 A randomized, open-label, multicenter, 4-week study to evaluate the tolerability and pharmacokinetics of itca 650 in patients with type 2 diabetes Clinical Therapeutics, May 22, 2013 Clinical Article
8 Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capacity in coronary artery disease patients with different stages of glucose tolerance Annals of Medicine, May 22, 2013 Evidence Based Medicine Clinical Article
9 Correlation between ankle-brachial index and microalbuminuria in type 2 diabetes mellitus Iranian Journal of Kidney Diseases, May 22, 2013 Clinical Article
10 Soccer training improves cardiac function in men with type 2 diabetes Medicine and Science in Sports and Exercise, May 22, 2013 Review Article
11 Erectile dysfunction may be the first clinical sign of insulin resistance and endothelial dysfunction in young men Clinical Research in Cardiology, May 22, 2013 Clinical Article
12 Renal function following three distinct weight loss dietary strategies during 2 years of randomized controlled trial Diabetes Care, May 22, 2013 Clinical Article
13 Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans Annals of Medicine, May 22, 2013 Evidence Based Medicine Clinical Article
14 Efficacy of cinacalcet with low-dose vitamin D in incident haemodialysis subjects with secondary hyperparathyroidism Nephrology Dialysis Transplantation, May 22, 2013 Clinical Article
15 Hyperglycemia after kidney transplantation: frequency and risk factors Iranian Journal of Kidney Diseases, May 22, 2013 Clinical Article
16 Renal lesions predict progression of diabetic nephropathy in type 1 diabetes Journal of the American Society of Nephrology, May 22, 2013 Clinical Article
17 Metabolic inflammation: Connecting obesity and insulin resistance Annals of Medicine, May 22, 2013 Review Article Clinical Article
18 Detection of BRAF V600E Mutation With Thyroid Tissue Using Pyrosequencing: Comparison With PNA-Clamping and Real-Time PCR American Journal of Clinical Pathology, May 22, 2013 Clinical Article
19 Pharmacology of amg 416 (velcalcetide), a novel peptide agonist of the calcium sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients Journal of Pharmacology and Experimental Therapeutics, May 22, 2013 Review Article
20 Retinoid acid receptor expression is helpful to distinguish between adenoma and well-differentiated carcinoma in the thyroid Virchows Archiv, May 22, 2013 Clinical Article
As published in Pancreas, researchers at the Bowman Gray School of Medicine have identified a protein (islet homeostasis protein [IHoP]) which appears to control blood glucose levels by regulating the balance between insulin and glucagon. IHoP is released from glucagon-producing cells in the islets. In both humans and animals, high levels of IHoP exist in the euglycemic state, while T1DM is associated with an absence of IHoP. The authors suggest that IHoP may serve as a target in the treatment of T1DM.
Read the article summaryAs reported in the Archives of Internal Medicine, researchers at the Mayo Clinic have shown an association between statin use and diabetes mellitus in postmenopausal women. The study involved 161,808 postmenopausal women (age range, 50-79 years) who were enrolled at 40 centers between 1993 and 1998 as part of the Women’s Health Initiative. Of the study cohort, data was available for 153,840 women without diabetes at baseline, 7.04% of whom used statins. There were 10,242 incident cases of diabetes in statin users (HR = 1.71) during 1,004,466 person-years of follow-up
Read the article summaryAnthropometric, laboratory, and clinical findings were evaluated in 681 patients with type 2 diabetes mellitus to determine the factors with the greatest influence on determining the basal insulin dosage for a target glucose level < 120 mg/dL. The authors reported that waist circumference, the duration of insulin treatment, lipid-lowering medications, use of insulin sensitizers, the HbA1c, fasting plasma glucose, HDL-C, and triglycerides levels, and severe NAFLD were most significant.
Read the article summary1 Over-the-Counter-Drug-Induced Thyroid Disorders Endocrine Practice, March 26, 2013 Free full text
2 Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidism: A Randomized, Double-Blind, Crossover Study Journal of Clinical Endocrinology and Metabolism, March 29, 2013
3 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013
4 Treatment of Diabetic Ketoacidosis (DKA) with 2 Different Regimens Regarding Fluid Substitution and Insulin Dosage (0.025 vs. 0.1 units/kg/h) Experimental and Clinical Endocrinology & Diabetes, February 13, 2012
5 Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired {beta}-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study Journal of Clinical Endocrinology and Metabolism, April 5, 2013
6 Very Low Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and Beta-Cell Function in Type 2 Diabetic Patients Diabetes, April 24, 2013 Review Article
7 Relationships Between Serum Adiponectin and Bone Density, Adiposity and Calcified Atherosclerotic Plaque in the African American-Diabetes Heart Study Journal of Clinical Endocrinology and Metabolism, April 2, 2013 Review Article
8 Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: A meta-analysis of cohort studies Diabetes Research and Clinical Practice, April 23, 2013 Evidence Based Medicine
9 A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review Diabetes, Obesity and Metabolism, April 4, 2013 Evidence Based Medicine Review Article
10 Significance of estimating the glomerular filtration rate for the management of hypertension in type 2 diabetes with microalbuminuria Hypertension Research, April 8, 2013
11 Validation of a Novel Method for Determining the Renal Threshold for Glucose Excretion in Untreated and Canagliflozin-treated Subjects With Type 2 Diabetes Mellitus Journal of Clinical Endocrinology and Metabolism, April 15, 2013
12 Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition) Journal of Bone and Mineral Metabolism, February 5, 2013 Clinical Guideline
13 Secular Changes in U.S. Prediabetes Prevalence Defined by Hemoglobin A1c and Fasting Plasma Glucose: National Health and Nutrition Examination Surveys, 1999-2010 Diabetes Care, April 22, 2013
14 Mechanisms of Glucose Lowering of Dipeptidyl Peptidase-4 Inhibitor Sitagliptin When Used Alone or With Metformin in Type 2 Diabetes: A double-tracer study Diabetes Care, April 17, 2013
15 Treatment with the long-acting insulin analogues detemir or glargine during pregnancy in women with type 1 diabetes: comparison of glycaemic control and pregnancy outcome The Journal of Maternal-Fetal and Neonatal Medicine, April 3, 2013
16 Randomized trial of Metformin versus Insulin in the Management of Gestational Diabetes American Journal of Obstetrics and Gynecology, April 19, 2013
17 Effects of patient-tailored atorvastatin therapy on ameliorating the levels of atherogenic lipids and inflammation beyond lowering low-density lipoprotein cholesterol in patients with type 2 diabetes Journal of Diabetes Investigation, April 3, 2013 Review Article
18 Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials Cardiovascular Diabetology, April 12, 2013 Free full text
19 Metformin and Sulfonylureas in Relation to Cancer Risk in Type II Diabetes Patients: A Meta-analysis using primary data of published studies Metabolism, February 19, 2013 Evidence Based Medicine
20 Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled With Newly Initiated and Continuously Titrated Basal Insulin Glargine: A 24-Week, Randomized, Placebo-Controlled Study (GETGOAL-DUO-1) Diabetes Care, April 8, 2013
Indexed Journals in Endocrinology: Endocrinology, Journal of Endocrinology, Clinical Endocrinology, Diabetes more
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