Parenteral vitamin D improves insulin sensitivity
As reported in Swiss Medical Weekly, supplemental vitamin D3 (300,000 IU im) in patients (n=55) with T2DM of > 10 y duration resulted in a 12.8% decrease in HOMA-IR at 6 months compared to an increase of 10% in patients who received placebo.
Vildegliptin superior to glimepiride when added to metformin
As reported in Metabolism, addition of vildegliptin (50 mg bid) to metformin in T2DM patients inadequately controlled on metformin alone was superior to the addition of glimepiride (2 mg tid) to metformin. Patients on the vildegliptin + metformin regimen lost more weight, had an improved lipid profile, had increased insulin sensitivity, and decreased post-prandial lipemia and insulinemia compared to patients on the glimepiride + metformin regimen.
Aspirin has a dose-independent effect in T2DM
As reported in The International Journal of Clinical Practice, the dose of aspirin (75 mg/d, 300 mg/d, or 3.6 g/d) had an independent effect on markers of vascular inflammation, oxidative stress, insulin resistance, and endothelial function in patients with T2DM (n=17; mean age = 57.4 y).