Emergency Med Medical News

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Use of Antiemetic Agents in Acute Gastroenteritis

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Debunking Myths in the US Healthcare System

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort
Virchows Archiv, 11/17/09

AuthorLastNameFI et al. – IL-10 over-expression (along with HR-HPV) was one of the independent covariates of CIN2/3. This immunosuppressive cytokine might play an important role in creating a microenvironment that favors progressive cervical disease and immune evasion by HR-HPV.

Methods

Baseline cervical biopsies from 225 women of LAMS study sub-cohort analyzed for IL-10 expression using immunohistochemistry, to assess its associations with CIN grade, and high-risk HPV (HR-HPV) at baseline, as well as in predicting outcomes of HR-HPV infections, and development of incident CIN1+ and CIN2+ in this longitudinal setting

Results

Expression of IL-10 in cervical lesions up-regulated most often in high-grade CIN, and IL-10 over-expression retained its value as independent predictor of CIN2+ (odds ratio (OR)?=?4.92) and CIN3+ (OR?=?7.51) also in multivariate model, including HR-HPV and several known covariates of IL-10 expression
Up-regulation not related to HR-HPV detection, and showed no relationship to HR-HPV viral loads
Using longitudinal predictive indicators (SE, SP, PPV, NPV), IL-10 expression of no value in predicting (1) outcomes of HR-HPV infections, or (2) surrogate endpoints (incident CIN1+, CIN2+) of progressive disease