Emergency Med Medical News about Migraine Disorders Calcitonin Gene-Related Peptide Saliva Rizatriptan

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Elevated Saliva Calcitonin Gene-Related Peptide Levels During Acute Migraine Predict Therapeutic Response to Rizatriptan
Headache: The Journal of Head and Face Pain, 10/14/09

Cady RK et al. – Elevation of saliva calcitonin gene–related peptide (CGRP) is predictive of responsiveness to rizatriptan. In the rizatriptan responsive population, CGRP levels are elevated beginning with the premonitory period and throughout mild and moderate/severe headache. Successful response to rizatriptan correlated with return of saliva CGRP levels to near baseline (interictal) values.

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