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Behringer W et al. – Out–of–hospital cooling has been shown to be feasible and safe by means of intravenous infusion with cold fluids or non–invasively with cooling pads. A combination of these cooling methods might further improve cooling efficacy. If out–of–hospital cooling will further improve functional outcome as compared with in–hospital cooling needs to be determined in a prospective, randomised, sufficiently powered clinical trial.

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