Emergency Med Medical News about Sciatica Lornoxicam

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Efficacy and safety of lornoxicam compared with placebo and diclofenac in acute sciatica/lumbo-sciatica: an analysis from a randomised, double-blind, multicentre, parallel-group study
International Journal of Clinical Practice, 10/12/09

Herrmann WA et al. – These data indicate that the analgesic efficacy of lornoxicam (LNX) is superior to placebo and similar to diclofenac in acute sciatica/lumbo–sciatica.

Methods

Male or female patients (n = 171) aged 18–70 years with acute sciatica or lumbo–sciatica.
The dosage of study treatment was 8–24 mg/day LNX, 100–150 mg/day diclofenac or placebo.

Results

In total, 164 patients completed the study.
Significant differences in PID between LNX and placebo were seen in the time interval 3–8 h after the first dose including pain intensity difference from baseline to 6 h (PID0–6 h).
Secondary end–points favoured LNX vs. placebo, but in general were not significantly different.
LNX and diclofenac had similar analgesic effect. Incidence and severity of adverse events were comparable for the three treatments; overall tolerability was rated as very good/good by 93% of the patients.

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