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See Latest ArticlesReactive species and pulmonary edema
Expert Review of Respiratory Medicine, 10/13/09
Iles KE et al. – Reactive oxygen and nitrogen species (RONS) can modify or damage ion channels, such as epithelial sodium channels, which alters fluid balance. Experimental systems in which either RONS are increased or protective antioxidant mechanisms are decreased result in alterations of epithelial sodium channel activity and support the hypothesis that RONS are important in NPE. Both basic and clinical studies are needed to critically define the RONS–NPE connection and the capacity of antioxidant therapy (either alone or as a supplement to beta–agonists) to improve patient outcome.
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