Emergency Med Medical News about pain; burn injury; hyperexcitability of second-order sensory neurons

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Unilateral Focal Burn Injury Is Followed by Long-Lasting Bilateral Allodynia and Neuronal Hyperexcitability in Spinal Cord Dorsal Horn
The Journal of Pain, 09/11/09

Chang Y–W et al. – Mechanisms contributing to pain following burn injury are incompletely understood. In a novel animal model of burn injury, the authors have demonstrated hyperexcitability of second–order sensory neurons, activation of microglia, and chronic bilateral pain following the burn injury. This work identifies potential therapeutic targets to alleviate pain after burn injury.

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