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See Latest ArticlesTonabersat, a novel gap-junction modulator for the prevention of migraine
Cephalalgia, 09/09/09
Silberstein SD – Recent research has pointed to the role of cortical spreading depression in the genesis of migraine aura and pain, with neuronal–glial gap junctions playing a prominent part in cortical spreading depression. Tonabersat is a unique compound with demonstrated activity as a gap–junction inhibitor in animal studies. In preclinical and clinical trials, tonabersat was well tolerated, with no cardiovascular effects; the pharmacokinetic profile suggested its usefulness in the prophylaxis of migraine.
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