Emergency Med Medical News about heart failure

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New treatment concepts for acute decompensated heart failure
Intensivmedizin und Notfallmedizin, 08/24/09

Lehinant SA et al. – There are new concepts for the treatment of acute decompensated heart failure. Several novel drugs act by modifying guanylate cyclase. Nesiritide and ularitide are natriuretic peptides acting on particulate guanylate cyclase. Cinaciguat is a novel soluble guanylate cyclase activator. Cinaciguat has a promising and novel mode of action: it activates cGMP synthesis by targeting sGC in its nitric oxide–insensitive, oxidized ferric or heme–free state. Preliminary studies of cinaciguat in patients with acute decompensated heart failure show substantial improvements in hemodynamics and symptoms, while maintaining renal function.

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Heart failure may worsen with statins
CNN Health, 11/06/09 Relevance Score: 71%

Death and Dying in Heart Failure With Normal Ejection Fraction
The American Journal of Cardiology, 10/27/09 Relevance Score: 70%

Physician-Determined Worsening Heart Failure: A Novel Definition for Early Worsening Heart Failure in Patients Hospitalized for Acute Heart Failure - Association with Signs and Symptoms, Hospitalization Duration, and 60-Day Outcomes
Cardiology, 10/22/09 Relevance Score: 70%

Fatigue in elderly with chronic heart failure: an under-recognized symptom
Aging Health, 10/14/09 Relevance Score: 70%

Central Aortic Stiffness is Increased in Patients With Heart Failure and Preserved Ejection Fraction
Journal of Cardiac Failure, 10/05/09 Relevance Score: 70%