Emergency Med Medical News about acute pain treatment; tapentadol

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New option for acute pain treatment
The Clinical Advisor, 08/19/09

Tapentadol is a centrally–acting synthetic analgesic. Although its mechanism of action is unknown, analgesic efficacy is thought to be due to mu–opioid agonist activity and the inhibition of norepinephrine reuptake. Two randomized, double–blind, placebo– and active– controlled studies were conducted to evaluate the efficacy and safety of tapentadol.

In the bunionectomy study, patients 18–80 years of age with moderate–to–severe pain following unilateral, first metatarsal bunionectomy surgery were given tapentadol 50 mg, 75 mg, 100 mg, or placebo every four to six hours for 72 hours. The proportion of patients who showed reduction in pain intensity at 48 hours of >=30% or >=50% were significantly higher in patients treated with tapentadol at each dose vs. placebo.
In the end–stage degenerative joint disease study, patients age 18–80 years with moderate–to–severe pain from end–stage degenerative joint disease of the hip or knee were given tapentadol 50 mg, 75 mg, or placebo every four to six hours for 10 days. The proportion of patients who showed reductions in pain at five days of >=30%, or >=50% were significantly higher in patients treated with tapentadol at each dose vs. placebo.

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Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 10/19/09 Relevance Score: 82%

The efficacy of topical thiocolchicoside (Muscoril) in the treatment of acute cervical myofascial pain syndrome: a single-blind, randomized, prospective, phase IV clinical study
Agri, 10/01/09 Relevance Score: 82%

Critical role of nociceptor plasticity in chronic pain
Trends in Neurosciences, 10/02/09 Relevance Score: 81%