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See Latest ArticlesPharmacology of oxycodone: does it explain why oxycodone has become a bestselling strong opioid?
Scandinavian Journal of Pain, 08/17/09
Lemberg KK et al. – Oxycodone is an old analgesic that has been in clinical use for decades. Its increased use in both acute and chronic pain has resulted in much research in both its basic and clinical pharmacology. It now appears that oxycodone is a selective m–opioid receptor agonist that has some distinct features that make it different from morphine: it has a faster passage to the CNS, it is not effective as a spinal analgesic, and it is metabolized through CYP 3A4 and 2D6 isoenzymes and thus prone to drug drug interactions. Some of the individual differences in the analgesic efficacy of oxycodone can be due to pharmacogenetic differences. Oxycodone is an effective analgesic but its more liberal use has also increased iatrogenic addiction and individuals seeking detoxification from oxycodone. Morphine may be less addictive than oxycodone but this assumption needs more research, which is not biased by increased use due to marketing.
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