Emergency Med Medical News about central post-stroke pain, sensory loss, neuronal hyperexcitability

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Central post-stroke pain: Clinical characteristics, pathophysiology, and management
The Lancet Neurology, 08/12/09

Klit H et al. – A review of central post-stroke pain (CPSP) focuses on clinical characteristics, pathophysiology, and management. Future prospective studies with clear diagnostic criteria are essential for interpretation of epidemiological data.

Methods

Review of clinical characteristics, pathophysiology, and management for CPSP

Results

CPSP: neuropathic pain syndrome after cerebrovascular accident
Characterization by pain and sensory abnormalities in body parts corresponding to brain territory injured by cerebrovascular lesion
Presence of sensory loss and signs of hypersensitivity in painful area in CPSP pts may indicate dual combination of deafferentation and subsequent development of neuronal hyperexcitability
Prevalence of CPSP unknown, partly due to difficulty in distinction from other post-stroke pain types
CPSP treatment: difficult but most effective approaches target increased neuronal hyperexcitability

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