Emergency Med Medical News about overdose of modified-release paracetamol

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Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption
New Zealand Medical Journal, 08/17/09

Graudins A et al. – Massive ingestion of modified–release paracetamol (Panadol Osteo) may result in biphasic and prolonged paracetamol absorption requiring extended administration of N–acetylcysteine. Current intravenous dosing regimens may not provide enough N–acetylcysteine to effectively metabolise paracetamol to non–toxic adducts.

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