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Prevalence and prognostic significance of transient, persistent, and new-onset anemia after acute myocardial infarction
The American Journal of Cardiology, 08/19/09

Hasin T et al. – Persistent or new-onset anemia occurs in a significant proportion of pts after acute myocardial infarction (AMI). Although resolution of anemia after AMI is associated with better outcomes, persistent or new-onset anemia portends increased risk for heart failure and death.

Methods

Study of 1,065 pts with AMIs with hemoglobin levels available postdischarge
Pt categorization by anemia status at hospital discharge and follow-up: 1) no anemia, 2) resolved anemia, 3) persistent anemia, 4) new-onset anemia
Primary endpoint: mortality and hospitalization for heart failure
Cox models to evaluated association between anemia and primary endpoint
Reference group: pts without anemia at the 2 time points

Results

At hospital discharge, anemia in 370 pts (34.7%)
At follow-up, anemia resolved in 162 pts (15.2%), persistent anemia in 208 (19.5%), new-onset anemia in 55 (5.2%)
During median 27-mo follow-up, 110 pts (10.3%) died; 89 (8.4%) developed heart failure
Outcomes of pts with resolving anemia similar to those of pts without anemia
Marked increase in mortality and heart failure in pts with persistent and new-onset anemia

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