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Cox NR et al. – ALF is a potentially life–threatening condition that can develop from various etiologies. Morbidity and mortality remain high. Management is focused on identifying the cause(s) of the liver insult and supportive management in the ICU, including liver transplantation when clinically indicated. Early recognition of the ALF–associated complications is paramount. Prognostic models may be helpful in identifying patients suitable for liver transplantation. More evidence is needed to determine if liver support systems have a definitive role in the management of ALF.

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