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Hemoglobinuria and Acute Kidney Injury Requiring Hemodialysis Following Intravenous Immunoglobulin Infusion
American Journal of Kidney Diseases, 07/30/09
Welles CC et al. – The authors present a case of a bone marrow transplant recipient who was treated with a sucrose–free IVIG product and subsequently developed Coombs–positive hemolysis leading to AKI requiring hemodialysis, who ultimately died secondary to infectious complications. The severity of this case emphasizes the importance of identifying populations who may be at increased risk of pigment–mediated kidney injury before consideration of IVIG therapy.
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