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See Latest ArticlesThe complexity of neurobiological processes in acute ischemic stroke
Clinical Neurology and Neurosurgery, 06/11/09
Brouns R et al. - In this review, the authors summarize the actual knowledge on the pathophysiology of acute ischemic stroke. The authors focus on the ischemic cascade, which is a complex series of neurochemical processes that are unleashed by transient or permanent focal cerebral ischemia and involves cellular bioenergetic failure, excitotoxicity, oxidative stress, blood–brain barrier dysfunction, microvascular injury, hemostatic activation, post-ischemic inflammation and finally cell death of neurons, glial and endothelial cells.
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