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Acute Disseminated Intravascular Coagulation
Hospital Physician, 05/26/09
Kusuma B et al. - DIC is a complex syndrome that involves thrombosis and hemorrhage secondary to an underlying condition. Trauma and sepsis are the major causes of DIC. Diagnosis of DIC requires recognition of underlying conditions and repeat measurements of coagulation parameters. Its management is dependent upon early recognition and correction of the underlying condition. Use of blood products is important in managing bleeding manifestations. Heparin use is controversial but is accepted in certain conditions where the thrombotic process predominates such as purpura fulminans, solid tumors, hemangiomas, and dead fetus syndrome. Other agents have been studied to manage thrombotic or hemorrhagic manifestations of DIC with varying results, and they require further study.
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