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A Large Prospective Observational Study of Novel Cyclosporine 0.1% Aqueous Ophthalmic Solution in the Treatment of Severe Allergic Conjunctivitis
Journal of Ocular Pharmacology and Therapeutics, 05/15/09
Ebihara N et al. - The percentage of patients able to complete topical cyclosporine 0.1% therapy within 6 months due to alleviation of symptoms was higher for VKC than for AKC. In both VKC and AKC, 30% of steroid users were able to discontinue topical steroids. Adverse drug reactions were found in 12.0% of patients, and the most common ADR was eye irritation. Infectious corneal complications were observed in five AKC patients, including two cases of bacterial corneal ulcer and three cases of herpetic keratitis; all of these patients were concomitantly using topical steroids. Topical cyclosporine 0.1% is an effective and safe treatment for VKC and AKC.
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