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Ex vivo Sputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma
American Journal of Respiratory and Critical Care Medicine, 05/11/09
Innes AL et al. - Rheological methods complimented by centrifugation-based mucin size profiling of airway mucins in health and acute asthma reveal that mucin degradation is inhibited in acute asthma, and that an excess of plasma proteins present in acute asthma inhibit the degradation of mucins in a protease dependent manner. These findings identify a novel mechanism whereby plasma exudation may impair airway mucus clearance.
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