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Acute lung injury during antithymocyte globulin therapy for aplastic anemia
Canadian Respiratory Journal, 05/01/09
Goligher EC et al. - The case of a 33-year-old man with aplastic anemia who experienced recurrent episodes of hypoxemia and pulmonary infiltrates during infusions of antithymocyte globulin is described. With the use of high-dose corticosteroids, the patient's original episodes resolved, and were subsequently prevented before additional administrations of ATG. Rare reports of an association between ATG and acute lung injury are found in the literature, but this is the first report of successful steroid-supported re-exposure.
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