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Reduced Production of Creatinine Limits Its Use as Marker of Kidney Injury in Sepsis
Journal of the American Society of Nephrology, 04/30/09

Doi K et al. - Sepsis reduces production of creatinine, which blunts the increase in serum creatinine after sepsis, potentially limiting the early detection of acute kidney injury. This may partially explain why small absolute increases in serum creatinine levels are associated with poor clinical outcomes. These data support the need for new biomarkers that provide better measures of renal injury, especially in patients with sepsis.

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