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See Latest ArticlesPediatric Ziprasidone Overdose
Pediatric Emergency Care, 04/29/09
Fasano CJ et al. - The mechanism of miosis associated with overdose of atypical antipsychotics is unclear but is likely related to interference with central innervation of the pupil. Pupil size is maintained by a balance between sympathetic and parasympathetic neurohumeral tones. The authors propose that an overdose of an alpha-1 receptor blocking agent, such as ziprasidone, results in unopposed parasympathetic stimulation resulting in miosis.
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