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Endothelin Receptor Antagonism and Renin Inhibition as Treatment Options for Scleroderma Kidney
American Journal of Kidney Diseases, 05/01/09
Dhaun N et al. - The authors present a case of SRC in a patient established on maximal tolerable RAAS-blocking treatment. This increase is considered acceptable after the introduction of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, is regarded as an indicator of drug efficacy, and confers longer term renal protection. Both endothelin receptor antagonism and direct renin inhibition offer alternate novel therapies for patients with SRC.
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