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Yang W et al. - Mailuoning, a type of Chinese traditional medicine, is widely used in the treatment of acute ischaemic stroke in China even though its efficacy is still uncertain. Animal experimental studies and clinical pharmacological research indicate that mailuoning could improve microcirculation, prevent ischaemic injury and protect heart and brain tissue. This review evaluated 15 randomised controlled trials, involving 1280 participants, of mailuoning for patients with acute ischaemic stroke. The authors found no convincing evidence, from trials with sufficient methodological quality, to support the routine use of mailuoning to promote recovery after stroke. High-quality and large-scale randomised controlled trials are needed to confirm its efficacy.

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