Emergency Med

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Variable effects of inhibiting inos and closing the vascular atp-sensitive potassium channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock
Shock, 04/27/09

O'Brien A et al. - Inhibition of the KATP channel via the pore-forming, but not the sulfonylurea receptor subunit, increases blood pressure in a short-term endotoxic model. However, this was not accompanied by any improvement in macrocirculatory or microcirculatory organ blood flow nor reversal of metabolic acidosis. It therefore remains uncertain whether the iNOS pathway or the KATP channel represents a potential target for drug development in the treatment of endotoxic shock.

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