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See Latest ArticlesLosartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor[kappa]b and mitogen-activated protein kinases
Shock, 04/27/09
Shen L et al. - Losartan given after sepsis led to inhibition of lung tissue NF-[kappa]B activation, attenuated degradation of I[kappa]B-[alpha], and inhibited phosphorylation of p38MAPK, extracellular signal-regulated kinase 1/2, and c-Jun N-terminal kinase, pathways critical for cytokine release. The data reveal that losartan exerts a protective effect on ALI/ARDS, and this protective effect may be dependent, at least in part, on NF-[kappa]B and MAPK mechanisms.
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