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Evidence of acute primary occult hepatitis B virus infection in an Italian repeat blood donor
Transfusion, 04/02/09
Manzini P et al. - CCA deletion may have impacted the virus replication efficiency since it affects the overlapping reverse transcriptase “finger” domain of the polymerase gene. These findings define this case as an acute primary OBI, confirming the existence of this condition. NAT with high sensitivity is the only screening enabling prevention of HBV transmission by transfusion in such cases.
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