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See Latest ArticlesCytotoxicity and Genotoxicity induced by the pesticide Acephate on Cultured Human Peripheral Blood Lymphocytes
The Internet Journal of Toxicology , 03/10/09
Das P et al. - Acephate is a broad-spectrum organophosphate insecticide extensively used in India to control pests for agricultural and household purposes. The aim of this investigation was to determine its toxicity profile in-vitro, using lymphocytes from peripheral blood samples of healthy human donors. The authors found the LC50 of Acephate to be 45(micro)M as measured by Trypan blue dye exclusion method. Chromosomal analyses of the metaphase plates of the samples treated with sub-lethal concentrations of Acephate revealed satellite associations, chromatid breaks and gaps indicating its effect on chromosomes.
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