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Platelet-dense granule deficiency causes postoperative hemorrhage in patients receiving enoxaparin: a novel observation with dramatic clinical implications
The American Journal of Surgery, 03/16/09
Kligman MD et al. - All patients had normal preoperative platelet counts and coagulation profiles. Ten patients underwent hematologic evaluation: coagulation pathway parameters were normal in all; however, all patients had a markedly decreased number of platelet-dense granules. Platelet-dense granule deficiency may cause postoperative hemorrhage in patients receiving LMWH.
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