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Toxic Additives in Medications for Preterm Infants
BMJ - ADC - Fetal and Neonatal, 02/11/09

Whittaker A et al. - The 38 infants represented 53% of the eligible target group; 7/38 infants had chronic lung disease (CLD). During their in-patient stay, infants were exposed to over 20 excipients including ethanol and propylene glycol - chemicals associated with neuro-toxicity. Infants with CLD were exposed to higher levels of these toxins. Infants were also exposed to high levels of sorbitol with some infants being exposed to levels in excess of recommended guidelines for maximum exposure in adults. Excipient exposure is common in preterm infants including some potentially toxic excipients.

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