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See Latest ArticlesRoles of polymorphic enzymes CYP2D6 and CYP2C19 for in vitro metabolism of amitriptyline at therapeutic and toxic levels
Forensic Toxicology, 01/27/09
Jornil J et al. - The above results indicate that CYP2D6 or CYP2C19 are generally not likely to be critical enzymes related to accidental intoxication under treatment with amitriptyline, but other contributing factors would be important; for example, low levels of various CYP enzymes and/or drug-drug interactions resulting in inhibition of several CYP enzymes may cause amitriptyline poisoning.
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