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The retinal 'lozenge' or 'dull macular reflex' in Alport syndrome is associated with a severe retinopathy and early onset renal failure
British Journal of Ophthalmology, 11/24/08
Colville D et al. - Clinicians must be aware the ‘lozenge’ or ‘dull macular reflex’ described in Alport syndrome is not a normal variant but reflects a severe almost confluent perimacular dot and fleck retinopathy. This sign is useful diagnostically and also prognostically since it is associated with early onset renal failure.
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