Emergency Med Medical News about Adenovirus

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[gamma][delta]T Cells Initiate Acute Inflammation and Injury in Adenovirus-Infected Liver via Cytokine-Chemokine Cross Talk
Journal of Virology, 10/30/08

Ajuebor MN et al. - The study highlighted a key role for IFN-[gamma] and CXCL9 cross talk acting in a feedback loop to drive the proinflammatory effects of [gamma][delta]T cells during AdLacZ-mediated acute liver toxicity. Specifically, intracellular IFN-[gamma] produced by activated hepatic [gamma][delta]T cells interacts with hepatocytes to mediate hepatic CXCL9 production, with the consequent accumulation of CXCR3-bearing [gamma][delta]T cells in the liver to cause acute liver damage without vector clearance.

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Phase I Clinical Trial of an Adenovirus/Prostate-Specific Antigen Vaccine for Prostate Cancer: Safety and Immunologic Results
Clinical Cancer Research, 11/20/09 Relevance Score: 85%

Association between human adenovirus-36 and lipid disorders in Korean schoolchildren
International Journal of Obesity, 10/16/09 Relevance Score: 85%

Recombinant adenovirus encoding vasohibin prevents tumor angiogenesis and inhibits tumor growth
Cancer Science, 11/17/09 Relevance Score: 84%

Human obesity relationship with Ad36 adenovirus and insulin resistance
International Journal of Obesity, 10/14/09 Relevance Score: 84%

Persistence of Transgene Expression Influences CD8+ T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus
Journal of Virology, 11/18/09 Relevance Score: 83%