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Torsade de pointes caused by polypharmacy and substance abuse in a patient with human immunodeficiency virus
International Journal of Emergency Medicine, 08/26/08

Prosser JM et al. - This is a case report of a 57-year-old man with a history of human immunodeficiency syndrome on abacavir, nevirapine, tenofovir, voriconazole, and methadone presented to the emergency department with a chief complaint of new-onset seizures. The patient had multiple risk factors for prolonged QT syndrome including human immunodeficiency virus infection, methadone therapy, and polypharmacy leading to potential drug interactions. Physicians must be aware of multidrug interactions potentiating QT prolongation and leading to torsade de pointes.

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