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The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils
Journal of Critical Care, 05/16/08
Fung YL et al. - The phenotypic and functional changes observed in neutrophils in the critically ill indicate that they require a higher level of stimulus to become activated. This may represent an auto-protective mechanism where the neutrophils in the already inflamed host may, by this mechanism, avoid excessive inflammation reducing the risk of further host cell injury and death.
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