Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis Halfhide CP et al. - In infants with severe RSV bronchiolitis neutrophil activation starts in the blood and progresses as they are recruited into the airways. Total neutrophil TLR4 remains low in both compartments. TLR4 mRNA expression is unimpaired. This suggests neutrophil TLR4 expression is deficient in these infants, which may explain why they develop severe RSV bronchiolitis. [more...]
