Propofol infusion syndrome in patients with refractory status epilepticus: An 11-year clinical experience
Critical Care Medicine, 11/19/2009
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Iyer VN et al. – Propofol is a sedative, anesthetic, and antiepileptic agent that is frequently used in patients with refractory status epilepticus. Propofol infusion syndrome is a ... feared complication of propofol use, especially at high infusion rates for prolonged periods. The present study describes the use of propofol and its associated complications in patients with refractory status epilepticus. The prolonged use of large doses of propofol to treat refractory status ... with significant mortality and morbidity.
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A comparison between target-controlled and manually controlled propofol infusions in patients undergoing routine surgical procedures
European Journal of Anaesthesiology, 10/15/2009
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Chen G et al. – Titration of propofol to achieve a comparable depth of anaesthesia results in comparable propofol consumption and recovery variables regardless of the type of propofol administration. Propofol plasma ... concentration showed large interindividual variability.
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Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
Journal of Clinical Anesthesia, 10/19/2009
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Tasdogan M et al. – The objective is to compare the effects of an intravenous infusion of propofol and the alpha–2 adrenoceptor ... levels (interleukin [IL]–1, IL–6, and tumor necrosis factor [TNF]–?) and IAP. Dexmedetomidine infusion decreases TNF–a, IL–1, and IL–6 levels and IAP more than a propofol infusion.
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The Effect of Single-Dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: A Randomized, Double-Blind, Controlled Trial
Anesthesia & Analgesia, 11/19/2009
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Simmonds MK et al. – A single IV infusion of propofol 2.4 mg/kg produces a statistically significant, but not clinically meaningful, reduction in ... after infusion and does not reduce pain intensity or analgesic use. This study does not support this regimen of IV propofol for clinical management of CDH.
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Use of intravenous infusion sedation among mechanically ventilated patients in the United States
Critical Care Medicine, 11/19/2009
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Wunsch H et al. – The percentage of mechanically ventilated patients receiving intravenous infusion sedation has increased over time. Sedation with an infusion of propofol was much more common ... benzodiazepines or dexmedetomidine, even for patients mechanically ventilated beyond 96 hrs.
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Propofol Infusion Syndrome With Arrhythmia, Myocardial Fat Accumulation and Cardiac Failure
The American Journal of Cardiology, 10/13/2009
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Jorens PG et al. – The investigators describe a 12–year–old male patient with a fatal case of this so–called propofol infusion syndrome. Postmortem investigation showed not only the
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Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study
Critical Care, 11/03/2009
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Roberts RJ et al. – Despite using a conservative definition for PRIS, and only considering new–onset PRIS clinical manifestations, the incidence of PRIS slightly exceeds 1 ... propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large. These studies should also investigate the mechanism(s) and risk factors for PRIS.
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Prevention Of Propofol Injection Pain With Small-Dose Ketamine
Middle East Journal of Anesthesiology, 10/08/2009
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Zahedi H et al. – Propofol is a popular IV anesthetic induction drug that causes pain when given IV, the incidence of which is between 28%–90%. Administration of ketamine 100 microg.kg
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Intrathecal infusions for intractable cancer pain: A qualitative study of the impact on a case series of patients and caregivers
Pain Research and Management, 10/28/2009
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Hawley P et al. – The present study is a qualitative exploration of the impact of intrathecal pump implantation on cancer patients, and also the impact of the ... up to three interviews each. Twenty–four staff interviews took place. Patients' hopes and expectations were not always fully met, but the infusions had a profound positive effect on quality of life. Patients expressed anxiety about dependence on the device, and also on a few highly skilled ... infusion was very important, as was regular education about infusion management. Implanted intrathecal infusion devices are a necessary part of a tertiary level cancer pain management service for the unfortunate minority with intractable pain. Practical recommendations for care are made for ... palliative care programs contemplating offering intrathecal infusions.
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Early Cognitive Impairment After Sedation for Colonoscopy: The Effect of Adding Midazolam and/or Fentanyl to Propofol
Anesthesia & Analgesia, 10/21/2009
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Padmanabhan U et al. – Significant cognitive impairment was common at discharge from elective outpatient colonoscopy. However, the addition of midazolam and/or fentanyl to propofol sedation did not result in more cognitive impairment than the use of propofol alone
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