Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia
European Journal of Clinical Pharmacology, 05/17/2012
Varatharajan S et al. – This pilot study suggests that CBR1 RNA expression may be helpful in identifying AML patients at risk of developing resistance or toxicity to daunorubicin due to increased formation of DOL. Inhibition of CBR1 can be an option to improve the efficacy and prevent toxicity related to the treatment. Influence of daunorubicin and DOL plasma levels on clinical outcome, if any, remains to be evaluated.