Nebulized Budesonide Added to Standard Pediatric Emergency Department Treatment of Acute Asthma: A Randomized, Double-blind Trial Full Text
Academic Emergency Medicine,  Clinical Article

Upham BD et al.– For children 2 to 18 years of age treated in the emergency department (ED) for acute asthma, a single 2–mg dose of budesonide added to standard therapy did not improve asthma severity scores or other short–term ED–based outcomes.

Methods
  • The authors conducted a randomized, double-blind, placebo-controlled trial in a tertiary care, urban pediatric ED.
  • Patients 2 to 18 years of age with moderate to severe acute asthma were randomized to receive either a single 2-mg dose of budesonide inhalation suspension (BUD) or normal sterile saline (NSS) placebo, added to albuterol, ipratropium bromide (IB), and systemic corticosteroids (SCS).
  • The primary outcome was the difference in median asthma scores between treatment groups at 2 hours.
  • Secondary outcomes included differences in vital signs and hospitalization rates.

Results
  • A total of 180 patients were enrolled.
  • Treatment groups had similar baseline demographics, asthma scores, and vital signs.
  • A total of 169 patients (88 BUD, 81 NSS) were assessed for the primary outcome.
  • No significant difference was found between groups in the change in median asthma score at 2 hours (BUD –3, NSS –3, p=0.64).
  • Vital signs at 2 hours were also similar between groups.
  • Fifty-six children (62%) were admitted to the hospital in the BUD group and 55 (62%) in the NSS group (difference 0%, 95% confidence interval [CI]=–14% to 14%).
  • Neither multivariate adjustment nor planned subgroup analysis by inhaled corticosteroids (ICS) use prior to the ED significantly altered the results.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Emergency Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Emergency Medicine Articles

1 Does a single dose of intravenous dexamethasone reduce Symptoms in Emergency department patients with low Back pain and RAdiculopathy (SEBRA)? A double-blind randomised controlled trial Emergency Medicine Journal, August 22, 2014    Clinical Article

2 The efficacy of propofol vs. subcutaneous sumatriptan for treatment of acute migraine headaches in the emergency department: a double-blinded clinical trial Pain Practice, July 15, 2014    Clinical Article

3 Prognostic value of the electrocardiogram in patients with syncope: data from the group for syncope study in the emergency room (GESINUR) Heart Rhythm, August 11, 2014    Clinical Article

4 Prednisone for emergency department low back pain: A randomized controlled trial The Journal of Emergency Medicine, May 29, 2014    Clinical Article

5 Sleeping in moderate hypoxia at home for prevention of acute mountain sickness (AMS): A placebo-controlled, randomized double-blind study Wilderness & Environmental Medicine, August 27, 2014    Clinical Article

6 The NOTA study (non operative treatment for acute appendicitis): Prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis Annals of Surgery, June 18, 2014    Clinical Article

7 Diagnostic value of S100B protein in the differential diagnosis of acute vertigo in the emergency department Academic Emergency Medicine, August 28, 2014    Clinical Article

8 Factors influencing the development of antibiotic associated diarrhea in emergency department patients discharged home: Risk of administering intravenous antibiotics The American Journal of Emergency Medicine, August 6, 2014    Clinical Article

9 Glasgow motor scale alone is equivalent to Glasgow Coma Scale at identifying children at risk for serious traumatic brain injury The Journal of Trauma and Acute Care Surgery, August 13, 2014    Clinical Article

10 Efficacy and safety of out-of-hospital intravenous metoprolol administration in anterior ST-segment elevation acute myocardial infarction: insights from the METOCARD-CNIC trial Annals of Emergency Medicine, August 19, 2014    Clinical Article

11 Efficacy and safety of haloperidol prophylaxis for delirium prevention in older medical and surgical at-risk patients acutely admitted to hospital through the emergency department: study protocol of a multicenter, randomised, double-blind, placebo-controlled clinical trial Full Text BMC Geriatrics, August 29, 2014    Free full text    Clinical Article

12 An association between an educational intervention and a reduction in inappropriate troponin testing in patients presenting to an adult emergency department Internal Medicine Journal, August 1, 2014    Review Article

13 Intra-articular lidocaine versus intravenous analgesia and sedation for manual closed reduction of acute anterior shoulder dislocation: an updated meta-analysis Journal of Clinical Anesthesia, August 4, 2014    Evidence Based Medicine    Review Article    Clinical Article

14 Intracranial pressure versus cerebral perfusion pressure as a marker of outcomes in severe head injury: a prospective evaluation The American Journal of Surgery, August 4, 2014    Clinical Article

15 Daily protein intake and patient outcomes in severe acute kidney injury: Findings of the randomized evaluation of normal versus augmented level of replacement therapy (RENAL) trial Blood Purification, August 25, 2014    Clinical Article

16 Chinese herbal medicine (Weijing decoction) combined with pharmacotherapy for the treatment of acute exacerbations of chronic obstructive pulmonary disease Full Text Evidence-based Complementary and Alternative Medicine , August 7, 2014    Free full text    Clinical Article

17 Quantitative measurement of elasticity of the appendix using shear wave elastography in patients with suspected acute appendicitis PLOS ONE, August 12, 2014    Clinical Article

18 Comparison of short-term infusion regimens of n-acetylcysteine plus intravenous fluids, sodium bicarbonate plus intravenous fluids, and intravenous fluids alone for prevention of contrast-induced nephropathy in the emergency department Academic Emergency Medicine, July 10, 2014    Clinical Article

19 Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial The Lancet Respiratory Medicine, August 5, 2014    Clinical Article

20 Rescuer-limited cardiopulmonary resuscitation as an alternative to 2-min switched CPR in the setting of inhospital cardiac arrest: a randomised cross-over study Emergency Medicine Journal, August 22, 2014    Clinical Article

Indexed Journals in Emergency Medicine: Journal of Emergency Medicine, Annals of Emergency Medicine, Injurymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close