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Emergency Medicine - Clinical Pharmacology News & Articles
MDLinx.com is your one stop shop for the latest Emergency Medicine news articles and peer reviewed clinical journal articles categorized daily into various hot topics such as: Trauma, Emergency Medicine Services, Airway/Respiratory management, Toxicology and much more. Not only are we the quickest, writing summaries of every article with 24 hours of publication, but we are also your most efficient resource for up-to-the-minute literature in Emergency Medicine.
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Your Unread Messages in Emergency Medicine
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Articles
Latest (3) Full Text Articles (39)61 Pressure Ulcer Development and Vasopressor Agents in Adult Critical Care Patients: A Literature Review Full Text Ostomy Wound Management, April 16, 2013 Review Article
62 Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections Cochrane Reviews, April 15, 2013 Review Article
63 Methylene Blue for Distributive Shock: A Potential New Use of an Old Antidote Journal of Medical Toxicology, April 15, 2013 Clinical Article
64 Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction Patients RAPID (Rapid Activity of Platelet Inhibitor Drugs) Primary PCI Study JACC - Journal of the American College of Cardiology, April 12, 2013 Clinical Article
65 A meta-analysis of analgesic and sedative effects of dexmedetomidine in burn patients Burns, April 12, 2013 Clinical Article
66 Topical ozonated oil versus hyaluronic gel for the treatment of partial- to full-thickness second-degree burns: A prospective, comparative, single-blind, non-randomised, controlled clinical trial Burns, April 11, 2013 Review Article
67 Efficacy of debridement and wound cleansing with 2% hydrogen peroxide on graft take in the chronic-colonized burn wounds; a randomized controlled clinical trial Burns, April 11, 2013 Clinical Article
68 De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock Cochrane Reviews, April 11, 2013 Review Article
69 Administration of metoclopramide by infusion or bolus does not affect the incidence of drug-induced akathisia Emergency Medicine Australasia, April 10, 2013 Clinical Article
70 Proton Pump Inhibitors and Risk of 1-Year Mortality and Rehospitalization in Older Patients Discharged From Acute Care Hospitals Proton Pump Inhibitors in Older Patients JAMA Internal Medicine, April 10, 2013 Clinical Article
71 A Randomized Trial of Intravenous Ketorolac Versus Intravenous Metoclopramide Plus Diphenhydramine for Tension-Type and All Nonmigraine, Noncluster Recurrent Headaches Annals of Emergency Medicine, April 9, 2013 Clinical Article
72 Recombinant Activated Factor VII Use in Critically Ill Patients: Clinical Outcomes and Thromboembolic Events Annals of Pharmacotherapy, April 9, 2013 Review Article
73 Development of Pyloric Stenosis After a 4-Day Course of Oral Erythromycin Pediatric Emergency Care, April 9, 2013
74 Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events New England Journal of Medicine, April 8, 2013 Clinical Article
75 A comparative study of 1% silver sulphadiazine (Flammazine) versus an enzyme alginogel (Flaminal) in the treatment of partial thickness burns Burns, April 4, 2013 Clinical Article
76 A descriptive study of myoclonus associated with etomidate procedural sedation in the ED The American Journal of Emergency Medicine, April 4, 2013 Clinical Article
77 Population distribution of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C risk alleles for methotrexate toxicity in Israel Rheumatology International, April 4, 2013 Clinical Article
78 Treatment with an Oxazolidinone Antibiotic Inhibits Toxic Shock Syndrome Toxin-1 Production in MRSA-Infected Burn Wounds Journal of Burn Care & Research, April 2, 2013 Review Article
79 Thromboprophylaxis for trauma patients Cochrane Reviews, April 1, 2013 Review Article
80 Statins of high versus low cholesterol-lowering efficacy and the development of severe renal failure Pharmacoepidemiology and Drug Safety, March 29, 2013 Clinical Article
Clinical Pearls in Emergency Medicine
- Appendicitis is the most common pediatric gastrointestinal surgical emergency.
- Drug-eluting stent (DES) placement improves revascularization rates without increased 3-year hazard of adverse clinical outcomes among individuals undergoing emergency primary percutaneous coronary intervention due to ST-segment elevation myocardial infarctions (STEMIs).
- Using an accelerated diagnostic protocol (ADP) with Troponin 1 as the sole biomarker may successfully identify low short-term risk of major adverse coronary event (MACE), and decrease observation time among individuals who present to the ER with chest pain.
Highlights in Emergency Medicine
Procalcitonin and CRP predict identify high-risk children with appendicitis
As published in Pediatric Emergency Care, procalcitonin and CRP levels discriminate between children admitted with a diagnosis of acute appendicitis who may require closer monitoring. The study involved 111 children who were divided into 2 groups based on intra-operative diagnoses of appendicitis (n=69) and peritonitis (n=42). Patients with peritonitis, who were more likely to have complications and require intensive care unit admission, had significantly higher procalcitonin (0.15 vs. 4.95 ng/ml) and CRP levels (3 vs. 14.3 mg/dl) on admission than patients with appendicitis. Using a cut-off procalcitonin level of 0.18 ng/ml, the sensitivity, specificity, positive predictive value, and negative predictive value for peritonitis were 97%, 80%, 72%, and 89.3%, respectively. Using a cut-off CRP level of 3 mg/dl, the sensitivity, specificity, positive predictive value, and negative predictive value for peritonitis were 95%, 74%, 68%, and 96.2%, respectively.
Read the article summaryVomiting during acute stroke increases mortality
As published in the Emergency Medicine Journal, patients who vomit during acute strokes have an increased risk of mortality (HR=5.06). Of 1968 stroke patients enrolled in the study, 1349 had cerebral infarctions, 459 had cerebral hemorrhages, and 152 had subarachnoid hemorrhages; 14.5% of all stroke patients vomited during the acute stage of the stroke (cerebral infarction, 8.7%; cerebral hemorrhage, 23.7%; and subarachnoid hemorrhage, 36.8%).
Read the article summaryAssociation between tight glycemic control and hip fracture in diabetics
As published in the Journal of the American Geriatrics Society, patients with T2DM (mean age, 77.3 y; n=932) with a HbA1c < 6% (OR=3.01) or 6.1-7% (OR=2.34) are more likely to sustain a hip fracture than patients with a HbA1c > 8%. All patients had a HbA1c level determined within 3 months preceding the hip fracture. No differences in risk existed between patients treated with oral hypoglycemics or insulin.
Read the article summaryMost Popular Emergency Med Articles
Last month's top read Top Articles of 20121 Critical Care Management of Verapamil and Diltiazem Overdose With a Focus on Vasopressors: A 25-Year Experience at a Single Center Annals of Emergency Medicine, May 6, 2013 Review Article
2 Impact of Hydrocortisone Hemisuccinate Use on Outcome of Severe Scorpion-Envenomed Adult Patients American Journal of Therapeutics, May 10, 2013
3 Does Change of Catecholamine Use Improve the Outcome of Patients With Shock Admitted to Intensive Care Unit? American Journal of Therapeutics, May 7, 2013
4 Characterization of the designer benzodiazepine pyrazolam and its detectability in human serum and urine Forensic Toxicology, April 29, 2013
5 Impact of Early Methadone Initiation in Critically Injured Burn Patients: A Pilot Study Journal of Burn Care & Research, May 8, 2013
6 Time to First Antibiotics for Pneumonia is not Associated with In-Hospital Mortality The Journal of Emergency Medicine, March 4, 2013 Review Article
7 Effective strategy for improving instructions for analgesic use in the emergency department European Journal of Emergency Medicine, May 1, 2013 Review Article
8 Role of dexmedetomidine in adults in the intensive care unit: An update American Journal of Health-System Pharmacy, April 24, 2013
9 Parenteral Fish Oil Lipid Emulsions in the Critically Ill: A Systematic Review and Meta-Analysis Journal of Parenteral and Enteral Nutrition, April 29, 2013 Evidence Based Medicine Review Article
10 Death due to eosinophilic necrotizing myocarditis despite steroid treatment American Journal of Forensic Medicine and Pathology, May 28, 2013
11 The impact of antibiotic impregnated PICC lines on the incidence of bacteremia in a regional burn center Burns, May 9, 2013
12 Customizing Anaphylaxis Guidelines for Emergency Medicine The Journal of Emergency Medicine, May 3, 2013 Clinical Guideline
13 Efficacy and safety of low-dose subcutaneous diclofenac in the management of acute pain: a randomized double-blind trial Pain Practice, May 23, 2013
14 Safety and Efficacy of Intravenous Hypotonic 0.225% Sodium Chloride Infusion for the Treatment of Hypernatremia in Critically Ill Patients Nutrition in Clinical Practice, April 24, 2013
15 Quantification of the effect of clopidogrel on enzymatic infarct size related to a percutaneous coronary intervention in patients with acute coronary syndromes: insights from the CHAMPION percutaneous coronary intervention trial Coronary Artery Disease, May 1, 2013
16 Inappropriate Medication Administration Practices in Canadian Adult ICUs: A Multicenter, Cross-Sectional Observational Study Annals of Pharmacotherapy, April 30, 2013 Review Article
17 Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction New England Journal of Medicine, April 24, 2013
18 Randomized Clinical Trial of the 2 mg Hydromorphone Bolus Protocol Versus the “1+1” Hydromorphone Titration Protocol in Treatment of Acute, Severe Pain in the First Hour of Emergency Department Presentation Annals of Emergency Medicine, May 21, 2013
19 Propofol for procedural sedation in the emergency department: a qualitative systematic review Annals of Pharmacotherapy, May 28, 2013 Review Article
20
Evaluation of the association between postintubation hypotension and lidocaine administered as a premedication for rapid sequence intubation: A comparison between traditional regression methods and propensity score matching-based method
Journal of Acute Medicine, May 20, 2013
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Indexed Journals in Emergency Medicine: Journal of Emergency Medicine, Annals of Emergency Medicine, Injury more
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