Motor performance and functional exercise capacity in survivors of pediatric acute lymphoblastic leukemia
Pediatric Blood & Cancer, 07/05/2012
Hartman A et al. – At ≥5years after completion of acute lymphoblastic leukemia (ALL) treatment motor performance had improved significantly, but functional exercise capacity was significantly impaired.Methods
- Motor performance of pediatric ALL survivors, treated with Dutch Childhood Oncology Group ALL–9 protocol was measured with the movement–ABC at stop treatment and ≥5years later.
- At follow–up functional exercise capacity was also investigated using the 6–minute walk test (6MWT).
- Heart rate and oxygen saturation were measured with a portable pulse oximeter before and after the 6MWT.
- Nineteen boys and 15 girls, median age 12.3years (range: 9.0–18.7), median time since completion of chemotherapy 5.2years (5.0–7.1), participated.
- Mean height/age and weight/age were within the norm, whereas mean BMI/age was significantly increased (mean SDS 0.38, SEM 0.17, P=0.04).
- Motor performance had improved significantly (P=0.001).
- In contrast, functional exercise capacity at follow–up was significantly impaired (mean SDS–2.05, SEM 0.13, P<0.001).