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Routine blood tests as predictors of mortality in hip fracture patients
Injury, 06/22/2012
Laulund AS et al. – Biochemical markers at admission are valid predictors of mortality in hip fracture patients.
Methods- Eligible studies were observational studies with a study population larger than 150 subjects, a mean age above 60years and a study duration below 730days.
- Characteristics of studies and outcomes of all–cause mortality were extracted from the retrieved articles.
- Data were pooled across studies for the individual biomarker using random– or fixed–effect analysis.
- 15 eligible studies of 5 different markers on mortality were studied.
- The following markers were found to be of prognostic value on mortality in hip fracture patients: low haemoglobin (odds ratio, 2.78; 95% confidence interval, 2.17–3.55; P<0.00001, 3148 subjects included), low total lymphocyte count, TLC (odds ratio, 2.60; 95% confidence interval, 1.61–4.20; P<0.00001, 1689 subjects included), low albumin (odds ratio, 1.83; 95% confidence interval, 1.31–2.56; P=0.0004, 1680 subjects included), low albumin/low TLC (odds ratio, 3.00; 95% confidence interval, 1.81–4.99; P<0.0001, 704 subjects included), low albumin/high TLC (odds ratio, 3.39; 95% confidence interval, 1.83–6.29; P=0.0001, 704 subjects included), high creatinine (odds ratio, 1.58; 95% confidence interval, 1.25–1.99; P=0.0001, 3761 subjects included), and high PTH (odds ratio, 15.43; 95% confidence interval, 3.60–66.14; P=0.0002, 525 subjects included).
