Microvessel networks in pre-formed in artificial clinical grade dermal substitutes in vitro using cells from haematopoietic tissues

Burns, 06/12/2012

Both cord and adult blood cells formed 2D microvascular networks in vitro, although there was a significant difference in the functional capacity of adult and cord blood ECFCs. While co–culture of the latter within dermal substitutes Matriderm or Integra demonstrated the formation of 3D microvascular networks penetrating 100µm, enhanced expansion, while maintaining functional capacity, of adult blood cells is required for fully pre–vascularising the clinical grade acellular dermal substitutes used here prior to applying these to burns.

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