Serum Procalcitonin Concentration in the Evaluation of Febrile Infants 2 to 60 Days of Age
Pediatric Emergency Care, 05/08/2012
Woelker JU et al. – Procalcitonin concentration is a serological marker for identification of or exclusion of serious bacterial infections (SBIs) in infants aged 2 to 60days. The predictive value of procalcitonin (PCT) in combination with urinary white blood cell count may be clinically useful. A validation study is indicated.
Infants 2 to 60days of age with rectal temperature 38°C were enrolled between May 2004 and March 2007.
Blood was obtained from each, and PCT was assessed using BRAHMS PCT LIA method.
Information for identification of low-risk infants using RC was obtained.
Negative predictive value, sensitivity, specificity, and likelihood ratio of PCT were compared with the RC.
In univariate analysis, the components of RC and PCT were considered.
Variables holding a significant association with the absence of SBI were included in a backward stepwise logistic regression model with SBI as the dependent variable, creating new low risk criteria.
One hundred fifty-five patients were enrolled.
Thirteen (8.4%) had an SBI.
Procalcitonin concentration at a cutoff value of 0.26ng/mL is similar in sensitivity (92%) and better in specificity (64%) than RC.
A combination of urine white blood cell and PCT was the best model in the regression analysis.
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