Impact of Latent Viral Infections in Mechanically Ventilated Patients

Current Respiratory Medicine Reviews, 05/07/2012

Recent studies suggest that active infection with Cytomegalovirus (CMV), herpes simplex virus (HSV), EBV or human herpes virus 6 (HHV–6) is also relatively common in ICU patients. Furthermore, an association between the presence of a CMV or HSV infection and increased mortality in critically ill patients was found. At present it is not clear whether this is intrinsically related to the micro–organism itself or merely an indication of the patients deteriorating physical condition leading to viral reactivation. To date the value of ganciclovir and acyclovir prophylaxis and/or treatment is unclear.

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