Predictors of bony morbidity in children with acute lymphoblastic leukemia

Pediatric Blood & Cancer, 05/04/2012

Older age and lower lumbar spine (LS) bone mineral density (BMD) at diagnosis are predictors of lower LS–BMD during continuation therapy. Dexamethasone and lower LS–BMD during continuation therapy are associated with fractures. Using these variables it is feasible to develop a predictor model to define the risk of bony morbidity in children receiving ALL therapy.

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