Coffee consumption and risk of stroke: a meta-analysis of cohort studies

Central European Journal of Medicine, 03/20/2012

Zhang R et al. - This meta-analysis is strongly supportive of the hypothesis that coffee consumption at different level, reduces the risk of stroke.


  • The authors searched PubMed and Embase for all cohort studies on stroke and coffee consumption in humans with original data.
  • Data from 13 studies involving 12414 stroke cases among 492760 individuals were pooled.
  • The outcome considered was the occurrence of any type of stroke.
  • Fixed effect model was used for the analysis of pooled relative risk.
  • Heterogeneity was tested.
  • If any existed, randomized effect model was used.


  • Comparing with non coffee drinking, all coffee consumption could reduce total stroke by 11% (95%CI: 0.81, 0.97).
  • In women, coffee consumption could reduce stroke risk by 17% (95%CI: 0.79, 0.87).
  • Although there is no statistical difference in men, coffee consumption showed the tendency of decreasing stroke risk.
  • Light, moderate and heavy coffee consumption could reduce the all type stroke risk by 10% (95%CI: 0.85, 0.96), 14% (95%CI: 0.76, 0.97), and 17% (95%CI: 0.78, 0.89) respectively.

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