Risk Factors Associated with Delayed Diagnosis of Acute Pulmonary Embolism

The Journal of Emergency Medicine, 10/03/2011

Smith SB et al. – Older patients with cardiovascular comorbidities had longer times from emergency department (ED) arrival to computed tomography (CT) diagnosis. The data suggest that these patients represent more of a diagnostic challenge than those presenting with traditional risk factors for pulmonary embolism (PE), such as tachycardia and recent immobilization. Physicians should consider these factors to diagnosis acute PE promptly in the ED.


  • The authors studied 400 consecutive adults who presented to the ED with acute, symptomatic PE.
  • All patients were diagnosed by computed tomography (CT) angiography.
  • Early diagnosis was defined as CT diagnosis<12h from ED arrival, and delayed diagnosis as CT diagnosis>12h.
  • Univariate and multiple logistic regression models were used to identify factors associated with delayed diagnosis.
  • Odds ratios with 95% confidence intervals are reported.


  • The median time from arrival to diagnosis was 2.4h (interquartile range 1.4-7.6), and 73 (18.3%) patients had delayed diagnosis.
  • Patients aged>65 years and those with coronary artery disease or congestive heart failure had longer times from ED arrival to CT diagnosis, whereas patients with recent immobility had shorter times.
  • Patients diagnosed>12h were older and had higher rates of morbid obesity and coronary artery disease, whereas patients diagnosed<12h had higher rates of tachycardia.
  • In multiple regression modeling, tachycardia and recent immobility remained associated with early diagnosis, whereas morbid obesity remained associated with delayed diagnosis.

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