Emergency Medicine News & Articles

1 Changing sedative infusion from propofol to midazolam improves sublingual microcirculatory perfusion in patients with septic shock Journal of Critical Care, May 17, 2013
Penna GL et al. – The goal of this study was to explore possible microcirculatory alterations by changing sedative infusion from propofol to midazolam in patients with septic shock. In this study, sublingual microcirculatory perfusion improved when the infusion was changed from propofol to midazolam in patients with septic shock. This observation could not be explained by changes in systemic hemodynamics. Methods Patients (n=16) were sedated with propofol during the first 24hours ...

2 A dose study of remifentanil in combination with propofol during tracheobronchial foreign body removal in children Journal of Clinical Anesthesia, May 23, 2013
Teksan L et al. – The study aims to assess the effect of two different remifentanil infusion doses on hemodynamic stability and recovery characteristics in children undergoing tracheobronchial foreign body removal during rigid bronchoscopy. A remifentanil 0.2µg/kg/min infusion with propofol provides hemodynamic stability and early recovery in children undergoing foreign body removal during rigid bronchoscopy. Methods 70 ASA physical status 1 and 2 children, aged 3–12years, ...

3 Effect of propofol and sevoflurane on acid-base balance during pediatric heart catheterization Minerva Anestesiologica, June 4, 2013
Fudickar A et al. – propofol is routinely used for anesthesia during pediatric heart catheterization. propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined as bradycardia with progress to asystolia during propofol infusion. Metabolic acidosis is regarded as an early warning sign of PRIS. In this study the effect of propofol and sevoflurane on serum base excess, pH and lactate have been examined during pediatric heart catheterization. propofol but not ...

4 Target-controlled infusion (Propofol) versus inhaled anaesthetic (Sevoflurane) in patients undergoing shoulder arthroscopic surgery Indian Journal of Anaesthesia, April 12, 2013
Tantry TP et al. – This study aimed to compare the efficacy and convenience of target controlled infusion (TCI) of propofol and inhalational agent sevoflurane in patients undergoing shoulder arthroscopic surgery after preliminary inter–scalene blockade. TCI propofol appears to be superior to and more convenient than sevoflurane anaesthesia in inter–scalene blocked patients undergoing shoulder arthroscopy. Methods Of thirty four patients studied, seventeen received TCI propofol ...

5 Comparison of effects of thoracic epidural and intravenous administration of lidocaine on target-controlled infusion of propofol and tracheal intubation response during induction of anesthesia Journal of Cardiothoracic and Vascular Anesthesia, May 29, 2013
Yang W et al. – The study aims to compare the effects of thoracic epidural anesthesia (TEA) and intravenous (IV) lidocaine on the effect–site concentration (Ce) of propofol target–controlled infusion (TCI) and the intubation–induced stress responses during general IV anesthesia induction. Lidocaine administered via both TEA and IV decreased the induction doses of propofol and suppressed cardiovascular and stress responses to tracheal intubation. Administration of 2mg/kg of 2% lidocaine IV ...

6 High-Dose Propofol Reduces S-100β Protein and Neuron-Specific Enolase Levels in Patients Undergoing Cardiac Surgery Journal of Cardiothoracic and Vascular Anesthesia, April 5, 2013
Ma G et al. - Jinhua ChenThe authors investigated the effects of different target plasma concentrations of propofol on cerebral injury by measuring serum S-100β protein and neuron-specific enolase (NSE) levels in patients undergoing single-valve replacement with cardiopulmonary bypass (CPB). In the range of commonly used clinical concentrations, administration of a high dose of propofol during CPB attenuated the biochemical markers of brain damage as compared ...

7 Comparison of recovery profiles of propofol and sevoflurane anesthesia with bispectral index monitoring in percutaneous nephrolithotomy Korean Journal of Anesthesiology, March 29, 2013
Orhon ZN et al. - The aim of the study was to evaluate the comparative effects of propofol infusion versus sevoflurane for maintenance of anesthesia with respect to hemodynamics, recovery characteristics, nausea and vomiting in patients undergoing percutaneous nephrolithotomy. The present study which adjusted sevoflurane concentration and propofol infusion rate according to BIS values revealed that maintenance of anesthesia with sevoflurane is associated with faster recovery than ...

8 Pharmacodynamic evaluation and physical/chemical analysis of two formulations of propofol used in target-controlled infusion Revista Brasileira de Anestesiologia, March 7, 2013
Simoni RF et al. – The aim of this study was to analyze the physicochemical properties, pharmacodynamic effect, and pharmaceutical and clinical equivalence of the reference drug propofol as well as a similar formulation. There was no clinically significant difference between the use of propofol, reference Diprivan, and the similar Propovan during infusion. However, the recovery time was longer with the reference drug. Although analysis of both formulations studied show similar results ...

9 Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery Acta Anaesthesiologica Taiwanica, May 7, 2013
Bharti N et al. - Gabapentin is an inhibitory neurotransmitter of the central nervous system. This prospective randomized double-blind study was conducted to evaluate the effects of gabapentin on intraoperative propofol requirements, hemodynamic variables, and postoperative pain relief in breast cancer patients. Preoperative administration of gabapentin reduced intraoperative propofol requirements and postoperative analgesic consumption in breast cancer patients undergoing total ...

10 Small dose of propofol combined with dexamethasone for postoperative vomiting in pediatric Moyamoya disease patients: a prospective, observer-blinded, randomized controlled study Korean Journal of Anesthesiology, March 8, 2013
Kim J et al. – For effective postoperative antiemetic management in pediatric moyamoya disease patients receiving fentanyl based postoperative analgesia, a multimodal approach has been recommended. The uncertain efficacy of ondansetron for pediatric neurosurgical patients or the possible antiemetic effect of small dose of propofol motivated us to evaluate the preventive effect of a subhypnotic dose of propofol combined with dexamethasone on postoperative vomiting (POV), especially during ...